The Challenge and Opportunity
Our society has never aged more rapidly – one of the most visible symptoms of the changing demographics is the exponential increase in the incidence of age-related diseases such as cancer, cardiovascular diseases and osteoarthritis. Not only does ageing have a negative effect on the quality of life but it also causes a significant financial strain on both private and public sector – two-fifths of the NHS budget is spent on the citizens who are over 65 years old. Few effective products addressing these challenges are currently available and most of them focus on a single disease rather than adopting a more holistic approach to ageing.
Recently a new approach which has the potential of significantly alleviating these problems has been validated by a number of in vivo and in vitro studies. It has been demonstrated that senescent cells (cells which have ceased to replicate due to stress or replicative capacity exhaustion) are linked to many age-related diseases. Their removal has drastically increased mice healthspan (period of life free of serious disease).
Human population by age. Data from www.census.gov
Death cause by age group, USA 2013
Data from http://www.cdc.gov/injury/wisqars/leadingcauses.html
Our technology concept is rooted in the combination of two exciting research fields: synthetic biology and ageing research. We are constructing genetic circuits which will allow us to specifically target senescent cells while sparing the healthy ones. Our systems will screen for a large number of biomarkers and will therefore allow for a safe, precise and more efficient targeting.
2018 Oct - Article about senolytics in Guardian mentioning CellAge.
2017 May - Interview with LongeCity about ageing research and the plans for CellAge.
2017 Apr - CellAge announces a seed fundraising round.
2017 Apr - CellAge invited to Inspire Lunch Grow Competition finals (UK).
2017 Mar - CellAge invited to Imperial College London Business Competition finals (UK).
2017 Mar - CellAge invited to Entrepreneurship Club Venture Development finals.
2017 Feb - CellAge crowdfunding campaign ends, raising a total of $34,215.
2016 Dec - CellAge endorsed by Dr. Aubrey de Grey.
2016 Dec - CellAge Ask-Me-Anything session at Reddit.
2016 Dec - CellAge interview with Fight!Aging.
2016 Dec - CellAge interview with Startup Lithuania.
2016 Dec - CellAge launches a crowdfunding campaign on LifeSpan.io platform.
2016 Sep - CellAge invited to Life Science Baltics startup competition (Lithuania).
2016 Mar - CellAge invited into Termis-EU Business Competition finals (Sweden).